That is largely subjective depending on the situation at hand.
With a character like Khan (to stick with your example), the majority of the concentration should be on finding a suitable ethnic actor for the role given the characters history, fanbase and role within the material. For a character like Lex Luthor, he is more of a concept than a character, much like James Bond or even Superman in many respects, this is where the ideas of race/sexuality/age and even gender become more blurred and accessible within those character archetypes.
Meaning, that for the sake of providing a fresh take on a concept we've seen tackled in similar ways a hundred times, casting a Non-Caucasian could add a new spin on that concept, given that it implies certain points and dynamics that we haven't seen before. I'm not sure how you're implications have any negative connotations, they don't, I'm not sure I see the issue with filmmakers deciding that for the sake of combating a cinematic/storytelling trope they should cast a black actor in a role.
They've already done that with Fishburne as Perry White, although I'd think that might have something to do with how white the rest of the cast is.
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